Understanding Ras:'it ain't over'til it's over'
JM Shields, K Pruitt, A McFall, A Shaub, CJ Der - Trends in cell biology, 2000 - cell.com
JM Shields, K Pruitt, A McFall, A Shaub, CJ Der
Trends in cell biology, 2000•cell.comSince 1982, Ras has been the subject of intense research scrutiny, focused on determining
the role of aberrant Ras function in human cancers and defining the mechanism by which
Ras mediates its actions in normal and neoplastic cells. The long-term goal has been to
develop antagonists of Ras as novel approaches for cancer treatment. Although impressive
strides have been made in these endeavours, and our knowledge of Ras is quite extensive,
it appears that we are at the beginning, rather than at the end, of fully understanding Ras …
the role of aberrant Ras function in human cancers and defining the mechanism by which
Ras mediates its actions in normal and neoplastic cells. The long-term goal has been to
develop antagonists of Ras as novel approaches for cancer treatment. Although impressive
strides have been made in these endeavours, and our knowledge of Ras is quite extensive,
it appears that we are at the beginning, rather than at the end, of fully understanding Ras …
Abstract
Since 1982, Ras has been the subject of intense research scrutiny, focused on determining the role of aberrant Ras function in human cancers and defining the mechanism by which Ras mediates its actions in normal and neoplastic cells. The long-term goal has been to develop antagonists of Ras as novel approaches for cancer treatment. Although impressive strides have been made in these endeavours, and our knowledge of Ras is quite extensive, it appears that we are at the beginning, rather than at the end, of fully understanding Ras function. This review highlights new issues that have further complicated our efforts to understand Ras.
cell.com
