[HTML][HTML] Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity
C Martin, P Passilly-Degrace, M Chevrot, D Ancel… - Journal of lipid …, 2012 - ASBMB
Glucagon-like peptide-1 (GLP-1) signaling modulates sweet-taste sensitivity in the mouse.
Because circumvallate papillae (CVPs) express both GLP-1 and its receptor, a local
regulation has been suggested. However, whether dietary lipids are involved in this
regulation, as shown in the gut, is unknown. By using a combination of biochemical,
immunohistochemical, and behavioral approaches, the present data i) confirm the role of
GLP-1 signaling in the attraction for sucrose, ii) demonstrate that minute quantities of long …
Because circumvallate papillae (CVPs) express both GLP-1 and its receptor, a local
regulation has been suggested. However, whether dietary lipids are involved in this
regulation, as shown in the gut, is unknown. By using a combination of biochemical,
immunohistochemical, and behavioral approaches, the present data i) confirm the role of
GLP-1 signaling in the attraction for sucrose, ii) demonstrate that minute quantities of long …