Automatic quantitation of localized in vivo 1H spectra with LCModel
SW Provencher - NMR in Biomedicine: An International Journal …, 2001 - Wiley Online Library
SW Provencher
NMR in Biomedicine: An International Journal Devoted to the …, 2001•Wiley Online LibraryThe LCModel method analyzes an in vivo spectrum as a Linear Combination of Model in
vitro spectra from individual metabolite solutions. Complete model spectra, rather than
individual resonances, are used in order to incorporate maximum prior information into the
analysis. A nearly model‐free constrained regularization method automatically accounts for
the baseline and lineshape in vivo without imposing a restrictive parameterized form on
them. LCModel is automatic (non‐interactive) with no subjective input. Approximately …
vitro spectra from individual metabolite solutions. Complete model spectra, rather than
individual resonances, are used in order to incorporate maximum prior information into the
analysis. A nearly model‐free constrained regularization method automatically accounts for
the baseline and lineshape in vivo without imposing a restrictive parameterized form on
them. LCModel is automatic (non‐interactive) with no subjective input. Approximately …
Abstract
The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model in vitro spectra from individual metabolite solutions. Complete model spectra, rather than individual resonances, are used in order to incorporate maximum prior information into the analysis. A nearly model‐free constrained regularization method automatically accounts for the baseline and lineshape in vivo without imposing a restrictive parameterized form on them. LCModel is automatic (non‐interactive) with no subjective input. Approximately maximum‐likelihood estimates of the metabolite concentrations and their uncertainties (Cramér‐Rao lower bounds) are obtained. LCModel analyses of spectra from users with fields from 1.5 to 9.4 T and a wide range of sequences, particularly with short TE, are used here to illustrate the capabilities and limitations of LCModel and proton MRS. Copyright © 2001 John Wiley & Sons, Ltd. Ala Asp Cr GABA Glc Gln Glu GPC GSH Ins Lac NAA NAAG PC PCr PE Scyllo S/N Tau
Abbreviations used:
alanine
aspartate
creatine
γ‐aminobutyric acid
glucose
glutamine
glutamate
glycerophosphocholine
glutathione
myo‐inositol
lactate
N‐acetylaspartate
N‐acetylaspartylglutamate
phosphocholine
phosphocreatine
phosphoethanolamine
scyllo‐inositol
signal‐to‐noise ratio
taurine.
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