Catecholaminergic polymorphic ventricular tachycardia
A Leenhardt, I Denjoy, P Guicheney - Circulation: Arrhythmia and …, 2012 - Am Heart Assoc
A Leenhardt, I Denjoy, P Guicheney
Circulation: Arrhythmia and Electrophysiology, 2012•Am Heart AssocRyR2 shares close to 70% with 2 other mammalian RyR isoforms15: RyR1 and RyR3. RyR1
is predominantly found in skeletal muscle, where it is activated directly by the L-type Ca2+
channel (Cav1. 1) to release SR Ca2+ stores during skeletal muscle contraction. Mutations
in the RYR1 gene cause various muscle disorders, such as malignant hyperthermia or
central core diseases. 23
is predominantly found in skeletal muscle, where it is activated directly by the L-type Ca2+
channel (Cav1. 1) to release SR Ca2+ stores during skeletal muscle contraction. Mutations
in the RYR1 gene cause various muscle disorders, such as malignant hyperthermia or
central core diseases. 23
RyR2 shares close to 70% with 2 other mammalian RyR isoforms15: RyR1 and RyR3. RyR1 is predominantly found in skeletal muscle, where it is activated directly by the L-type Ca2+ channel (Cav1. 1) to release SR Ca2+ stores during skeletal muscle contraction. Mutations in the RYR1 gene cause various muscle disorders, such as malignant hyperthermia or central core diseases. 23
Am Heart Assoc