[HTML][HTML] Inhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose …
Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is caused by Ca 2+ entry
via voltage-dependent Ca 2+ channels. CaMKII is a key mediator and feedback regulator of
Ca 2+ signaling in many tissues, but its role in β-cells is poorly understood, especially in
vivo. Here, we report that mice with conditional inhibition of CaMKII in β-cells show
significantly impaired glucose tolerance due to decreased GSIS. Moreover, β-cell CaMKII
inhibition dramatically exacerbates glucose intolerance following exposure to a high fat diet …
via voltage-dependent Ca 2+ channels. CaMKII is a key mediator and feedback regulator of
Ca 2+ signaling in many tissues, but its role in β-cells is poorly understood, especially in
vivo. Here, we report that mice with conditional inhibition of CaMKII in β-cells show
significantly impaired glucose tolerance due to decreased GSIS. Moreover, β-cell CaMKII
inhibition dramatically exacerbates glucose intolerance following exposure to a high fat diet …