ErbB4 modulates tubular cell polarity and lumen diameter during kidney development
V Veikkolainen, F Naillat, A Railo, L Chi… - Journal of the …, 2012 - journals.lww.com
ErbB4 receptor tyrosine kinase contributes to the development of the heart, the central
nervous system, and the lactating mammary gland, but whether it has a role in the
development of the kidney epithelium is unknown. Here, we found that expression of Erbb4
isoforms JM-a CYT-1 and JM-a CYT-2 was first detectable around embryonic day 13 in the
mouse, mainly in the collecting ducts and both the proximal and distal tubules. In vitro,
overexpression of a relevant ErbB4 isoform promoted proliferation and disturbed …
nervous system, and the lactating mammary gland, but whether it has a role in the
development of the kidney epithelium is unknown. Here, we found that expression of Erbb4
isoforms JM-a CYT-1 and JM-a CYT-2 was first detectable around embryonic day 13 in the
mouse, mainly in the collecting ducts and both the proximal and distal tubules. In vitro,
overexpression of a relevant ErbB4 isoform promoted proliferation and disturbed …