Are renal ciliopathies (replication) stressed out?
GG Slaats, RH Giles - Trends in cell biology, 2015 - cell.com
GG Slaats, RH Giles
Trends in cell biology, 2015•cell.comJuvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since
all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia
loss. However, recent data suggest that DNA damage caused by replication stress, possibly
concomitant with or upstream of cilia dysfunction, causes NPHP.
all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia
loss. However, recent data suggest that DNA damage caused by replication stress, possibly
concomitant with or upstream of cilia dysfunction, causes NPHP.
Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunction, causes NPHP.
cell.com