Erythropoietin synthesis in renal myofibroblasts is restored by activation of hypoxia signaling

T Souma, M Nezu, D Nakano, S Yamazaki… - Journal of the …, 2016 - journals.lww.com
Erythropoietin (Epo) is produced by renal Epo-producing cells (REPs) in a hypoxia-inducible
manner. The conversion of REPs into myofibroblasts and coincident loss of Epo-producing
ability are the major cause of renal fibrosis and anemia. However, the hypoxic response of
these transformed myofibroblasts remains unclear. Here, we used complementary in vivo
transgenic and live imaging approaches to better understand the importance of hypoxia
signaling in Epo production. Live imaging of REPs in transgenic mice expressing green …