High perfusion pressure accelerates renal injury in salt-sensitive hypertension

T Mori, A Polichnowski, P Glocka… - Journal of the …, 2008 - journals.lww.com
Renal injury in the Dahl salt-sensitive rat mimics human salt-sensitive forms of hypertension
that are particularly prevalent in black individuals, but the mechanisms that lead to the
development of this injury are incompletely understood. We studied the impact of renal
perfusion pressure (RPP) on the development of renal injury in this model. During the
development of salt-induced hypertension over 2 wk, the RPP to the left kidney was
maintained at control levels (125±2 mmHg) by continuous servocontrol inflation of an aortic …