[PDF][PDF] The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells

R Yagi, C Zhong, DL Northrup, F Yu, N Bouladoux… - Immunity, 2014 - cell.com
R Yagi, C Zhong, DL Northrup, F Yu, N Bouladoux, S Spencer, G Hu, L Barron, S Sharma…
Immunity, 2014cell.com
Innate lymphoid cells (ILCs) are critical in innate immune responses to pathogens and
lymphoid organ development. Similar to CD4+ T helper (Th) cell subsets, ILC subsets
positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines.
However, the molecular control of IL-7Rα+ ILC development and maintenance is unclear.
Here, we report that GATA3 was indispensable for the development of all IL-7Rα+ ILC
subsets and T cells but was not required for the development of classical natural killer cells …
Summary
Innate lymphoid cells (ILCs) are critical in innate immune responses to pathogens and lymphoid organ development. Similar to CD4+ T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines. However, the molecular control of IL-7Rα+ ILC development and maintenance is unclear. Here, we report that GATA3 was indispensable for the development of all IL-7Rα+ ILC subsets and T cells but was not required for the development of classical natural killer cells. Conditionally Gata3-deficient mice had no lymph nodes and were susceptible to Citrobactor rodentium infection. After the ILCs had fully developed, GATA3 remained important for the maintenance and functions of ILC2s. Genome-wide gene expression analyses indicated that GATA3 regulated a similar set of cytokines and receptors in Th2 cells and ILC2s, but not in ILC3s. Thus, GATA3 plays parallel roles in regulating the development and functions of CD4+ T cells and IL-7Rα+ ILCs.
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