Signaling through OX40 enhances antitumor immunity

SM Jensen, LD Maston, MJ Gough, CE Ruby… - Seminars in …, 2010 - Elsevier
The existence of tumor-specific T cells, as well as their ability to be primed in cancer
patients, confirms that the immune response can be deployed to combat cancer. However,
there are obstacles that must be overcome to convert the ineffective immune response
commonly found in the tumor environment to one that leads to sustained destruction of
tumor. Members of the tumor necrosis factor (TNF) superfamily direct diverse immune
functions. OX40 and its ligand, OX40L, are key TNF members that augment T-cell …