[HTML][HTML] Functional significance of metastasis-inducing S100A4 (Mts1) in tumor-stroma interplay

B Schmidt-Hansen, J Klingelhöfer… - Journal of Biological …, 2004 - ASBMB
Causal implication of S100A4 in inducing metastases was convincingly shown previously.
However, the mechanisms that associate S100A4 with tumor progression are not well
understood. S100A4 protein, as a typical member of the S100 family, exhibits dual,
intracellular and extracellular, functions. This work is focused on the extracellular function of
S100A4, in particular its involvement in tumor-stroma interplay in VMR (mouse
adenocarcinoma cell line) tumor cells, which exhibit stroma-dependent metastatic …