Asymptomatic antibody-mediated rejection after heart transplantation predicts poor outcomes
GW Wu, JA Kobashigawa, MC Fishbein… - The Journal of heart and …, 2009 - Elsevier
BACKGROUND: Antibody-mediated rejection (AMR) has been associated with poor
outcome after heart transplantation. The diagnosis of AMR usually includes endomyocardial
biopsy findings of endothelial cell swelling, intravascular macrophages, C4d+ staining, and
associated left ventricular dysfunction. The significance of AMR findings in biopsy
specimens of asymptomatic heart transplant patients (normal cardiac function and no
symptoms of heart failure) is unclear. METHODS: Between July 1997 and September 2001 …
outcome after heart transplantation. The diagnosis of AMR usually includes endomyocardial
biopsy findings of endothelial cell swelling, intravascular macrophages, C4d+ staining, and
associated left ventricular dysfunction. The significance of AMR findings in biopsy
specimens of asymptomatic heart transplant patients (normal cardiac function and no
symptoms of heart failure) is unclear. METHODS: Between July 1997 and September 2001 …