Human monoclonal antibody derived from an autoimmune thrombocytopenic purpura patient, recognizing an intermediate filament's determinant common to vimentin …
D Varon, S Linder, E Gembom, L Guedg… - Clinical immunology and …, 1990 - Elsevier
Human monoclonal antibody (mAb) technology has been helpful in identifying
autoantibodies that are involved in various autoimmune disorders. We report here the
results of such an attempt to immortalize antibody-forming cells from spleen of an
autoimmune thrombocytopenic purpura (ATP) patient and characterize the resulting mAb.
The human mAb we derived, denoted (4G9), binds to the cytoskeletal network. Using
immunofluorescence analyses of permeabilized and fixed cell lines and tissues, the 4G9 …
autoantibodies that are involved in various autoimmune disorders. We report here the
results of such an attempt to immortalize antibody-forming cells from spleen of an
autoimmune thrombocytopenic purpura (ATP) patient and characterize the resulting mAb.
The human mAb we derived, denoted (4G9), binds to the cytoskeletal network. Using
immunofluorescence analyses of permeabilized and fixed cell lines and tissues, the 4G9 …
