Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris
Background An active disease mouse model of pemphigus vulgaris (PV) was developed
using the adoptive transfer of splenocytes from Dsg3−/− mice with a mixed C57BL/6J (B6)
and 129/Sv genetic background into B6-Rag2−/− mice. Further immunological investigation
is needed to resolve the genetic mismatch between host and recipient mice. The B6-
Dsg3−/− mice did not grow old enough to provide splenocytes, probably due to severe oral
erosions, with resulting inhibition of food intake. Objective To rescue the B6-Dsg3−/− mice …
using the adoptive transfer of splenocytes from Dsg3−/− mice with a mixed C57BL/6J (B6)
and 129/Sv genetic background into B6-Rag2−/− mice. Further immunological investigation
is needed to resolve the genetic mismatch between host and recipient mice. The B6-
Dsg3−/− mice did not grow old enough to provide splenocytes, probably due to severe oral
erosions, with resulting inhibition of food intake. Objective To rescue the B6-Dsg3−/− mice …