Genetic control of the fucosylation of ABH precursor chains. Evidence for new epistatic interactions in different cells and tissues
R Oriol - International Journal of Immunogenetics, 1990 - Wiley Online Library
International Journal of Immunogenetics, 1990•Wiley Online Library
The general structure of the ABH antigens is analysed taking into account six possible
precursor chains and two α‐2‐fucosyltransferases. The classical genetic model with one
structural gene and two regulatory genes for the synthesis of the H antigen and the events
which prompted the proposal of the new model with two structural genes for the synthesis of
H determinants are discussed. Three human α‐3‐fucosyltransferases with different acceptor
specificity are presented. Myeloid type of α‐3‐fucosyltransferase, which transfers fucose on …
precursor chains and two α‐2‐fucosyltransferases. The classical genetic model with one
structural gene and two regulatory genes for the synthesis of the H antigen and the events
which prompted the proposal of the new model with two structural genes for the synthesis of
H determinants are discussed. Three human α‐3‐fucosyltransferases with different acceptor
specificity are presented. Myeloid type of α‐3‐fucosyltransferase, which transfers fucose on …
Summary
The general structure of the ABH antigens is analysed taking into account six possible precursor chains and two α‐2‐fucosyltransferases. The classical genetic model with one structural gene and two regulatory genes for the synthesis of the H antigen and the events which prompted the proposal of the new model with two structural genes for the synthesis of H determinants are discussed.
Three human α‐3‐fucosyltransferases with different acceptor specificity are presented. Myeloid type of α‐3‐fucosyltransferase, which transfers fucose on to H type 2, serum type of α‐3‐fucosyltransferase, which transfers fucose on to H type 2 and sialyl‐N‐acetyl‐lactosamine and Lewis or α‐3/4‐fucosyltransferase, which transfers fucose on to H type 1 and H type 2 and the corresponding sialylated structures.
The presence of different ABH and Lewis antigens in different tissues and the different epistatic interactions needed to account for their synthesis are analysed in terms of new epistatic interactions with either the known fucosyltransferases or with new fucosyltransferases.
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