Genetic evidence for the involvement of lipid metabolism in Alzheimer's disease
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2010•Elsevier
Alzheimer's disease (AD) is the most common cause of dementia in the elderly and presents
a great burden to sufferers and to society. The genetics of rare Mendelian forms of AD have
been central to our understanding of AD pathogenesis for the past twenty years and now the
genetics of the common form of the disease in the elderly is beginning to be unravelled by
genome-wide association studies. Four new genes for common AD have been revealed in
the past year, CLU, CR1, PICALM and BIN1. Their possible involvement in lipid metabolism …
a great burden to sufferers and to society. The genetics of rare Mendelian forms of AD have
been central to our understanding of AD pathogenesis for the past twenty years and now the
genetics of the common form of the disease in the elderly is beginning to be unravelled by
genome-wide association studies. Four new genes for common AD have been revealed in
the past year, CLU, CR1, PICALM and BIN1. Their possible involvement in lipid metabolism …
Alzheimer's disease (AD) is the most common cause of dementia in the elderly and presents a great burden to sufferers and to society. The genetics of rare Mendelian forms of AD have been central to our understanding of AD pathogenesis for the past twenty years and now the genetics of the common form of the disease in the elderly is beginning to be unravelled by genome-wide association studies. Four new genes for common AD have been revealed in the past year, CLU, CR1, PICALM and BIN1. Their possible involvement in lipid metabolism and how that relates to AD is discussed here.
Elsevier
