Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory
F Wang, SY Ren, JF Chen, K Liu, RX Li, ZF Li… - Nature …, 2020 - nature.com
Nature neuroscience, 2020•nature.com
Cognitive decline remains an unaddressed problem for the elderly. We show that
myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with
spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte
precursor cells impairs spatial memory in young mice, while enhancing myelination by
deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or
promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues …
myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with
spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte
precursor cells impairs spatial memory in young mice, while enhancing myelination by
deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or
promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues …
Abstract
Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory in young mice, while enhancing myelination by deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues spatial memory decline during aging.
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