[HTML][HTML] Heparanase expression and activity are increased in platelets during clinical sepsis
AS Eustes, RA Campbell, EA Middleton… - Journal of Thrombosis …, 2021 - Elsevier
Background Heparanase (HPSE) is the only known mammalian enzyme that can degrade
heparan sulfate. Heparan sulfate proteoglycans are essential components of the glycocalyx,
and maintain physiological barriers between the blood and endothelial cells. HPSE
increases during sepsis, which contributes to injurious glyocalyx degradation, loss of
endothelial barrier function, and mortality. Objectives As platelets are one of the most
abundant cellular sources of HPSE, we sought to determine whether HPSE expression and …
heparan sulfate. Heparan sulfate proteoglycans are essential components of the glycocalyx,
and maintain physiological barriers between the blood and endothelial cells. HPSE
increases during sepsis, which contributes to injurious glyocalyx degradation, loss of
endothelial barrier function, and mortality. Objectives As platelets are one of the most
abundant cellular sources of HPSE, we sought to determine whether HPSE expression and …