The human paracaspase MALT1 is a caspase homolog that plays a central role in NF-κB
signaling. Over the past few years it has become clear that this is due to a combination of its
scaffolding and proteolytic function. Knockout mice and mice expressing a catalytically dead
variant of the protease have provided valuable information. This review aims to provide an
overview of recent developments regarding the enzymatic mechanism and specificity of
MALT1, its substrates discovered to date, different mouse models, as well as the role of …