Mantle cell lymphoma: recent insights into pathogenesis, clinical variability, and new diagnostic markers
B Sander - Seminars in diagnostic pathology, 2011 - Elsevier
Mantle cell lymphoma (MCL; previously called centrocytic lymphoma or lymphocytic
lymphoma of intermediate differentiation) is a distinct subtype of B-cell lymphoma,
accounting for approximately 3%-10% of all lymphoma diagnoses. The name refers to the
growth pattern in early disease presentation resembling the normal mantle zone that
surrounds the germinal center of the B-cell follicle. The hallmark of MCL is the t (11; 14)(q13;
q32), resulting in aberrant expression of the CCND1 gene and expression of cyclin D1 in the …
lymphoma of intermediate differentiation) is a distinct subtype of B-cell lymphoma,
accounting for approximately 3%-10% of all lymphoma diagnoses. The name refers to the
growth pattern in early disease presentation resembling the normal mantle zone that
surrounds the germinal center of the B-cell follicle. The hallmark of MCL is the t (11; 14)(q13;
q32), resulting in aberrant expression of the CCND1 gene and expression of cyclin D1 in the …