In-vivo antithrombotic potency of placenta protein 4 (annexin V)
J Römisch, D Seiffge, G Reiner, EP Pâques… - Thrombosis research, 1991 - Elsevier
The antithrombotic properties of Placenta Protein 4 (PP4) were investigated in laser or
photochemically induced thrombus formation models in rats. In both in-vivo test-systems
PP4 displayed a significant antithrombotic effect at dose levels as low as 0.3 and 1.0 mg/kg
body weight. Bleeding times, surprisingly, were not prolonged significantly at these dose
regimens. Maximal inhibition of thrombus formation in the laser-model was observed 15 min
after intravenous administration of PP4, but was not recognizable in a clear-cut reaction in …
photochemically induced thrombus formation models in rats. In both in-vivo test-systems
PP4 displayed a significant antithrombotic effect at dose levels as low as 0.3 and 1.0 mg/kg
body weight. Bleeding times, surprisingly, were not prolonged significantly at these dose
regimens. Maximal inhibition of thrombus formation in the laser-model was observed 15 min
after intravenous administration of PP4, but was not recognizable in a clear-cut reaction in …