[HTML][HTML] Exposure of phosphatidylserine by Xk-related protein family members during apoptosis
J Suzuki, E Imanishi, S Nagata - Journal of Biological Chemistry, 2014 - ASBMB
Apoptotic cells expose phosphatidylserine (PtdSer) on their surface as an" eat me" signal.
Mammalian Xk-related (Xkr) protein 8, which is predicted to contain six transmembrane
regions, and its Caenorhabditis elegans homolog CED-8 promote apoptotic PtdSer
exposure. The mouse and human Xkr families consist of eight and nine members,
respectively. Here, we found that mouse Xkr family members, with the exception of Xkr2, are
localized to the plasma membrane. When Xkr8-deficient cells, which do not expose PtdSer …
Mammalian Xk-related (Xkr) protein 8, which is predicted to contain six transmembrane
regions, and its Caenorhabditis elegans homolog CED-8 promote apoptotic PtdSer
exposure. The mouse and human Xkr families consist of eight and nine members,
respectively. Here, we found that mouse Xkr family members, with the exception of Xkr2, are
localized to the plasma membrane. When Xkr8-deficient cells, which do not expose PtdSer …