[HTML][HTML] Human type IV P-type ATPases that work as plasma membrane phospholipid flippases and their regulation by caspase and calcium
K Segawa, S Kurata, S Nagata - Journal of Biological Chemistry, 2016 - ASBMB
In plasma membranes, flippases translocate aminophospholipids such as
phosphatidylserine and phosphatidylethanolamine from the extracellular to the cytoplasmic
leaflet. Mammalian ATP11C, a type IV P-type ATPase, acts as a flippase at the plasma
membrane. Here, by expressing 12 human type IV P-type ATPases in ATP11C-deficient
cells, we determined that ATP8A2 and ATP11A can also act as plasma membrane flippases.
As with ATP11C, ATP8A2 and ATP11A localized to the plasma membrane in a CDC50A …
phosphatidylserine and phosphatidylethanolamine from the extracellular to the cytoplasmic
leaflet. Mammalian ATP11C, a type IV P-type ATPase, acts as a flippase at the plasma
membrane. Here, by expressing 12 human type IV P-type ATPases in ATP11C-deficient
cells, we determined that ATP8A2 and ATP11A can also act as plasma membrane flippases.
As with ATP11C, ATP8A2 and ATP11A localized to the plasma membrane in a CDC50A …