Cellular senescence is a state of cell cycle arrest induced by several forms of metabolic
stress. Senescent cells accumulate with advancing age and have a distinctive phenotype,
characterized by profound chromatin alterations and a robust senescence-associated
secretory phenotype (SASP) that exerts negative effects on tissue health, both locally and
systemically. In preclinical models, pharmacological agents that eliminate senescent cells
(senotherapeutics) restore health and youthful properties in multiple tissues. To date …