Infectious agents have intimately co-evolved with the host immune system, acquiring a
portfolio of highly sophisticated mechanisms to modulate immunity. Among the common
strategies developed by viruses, bacteria, protozoa, helminths, and fungi is the manipulation
of the regulatory T cell network in order to favor pathogen survival and transmission. Treg
activity also benefits the host in many circumstances by controlling immunopathogenic
reactions to infection. Interestingly, some pathogens are able to directly induce the …