Tonicity-responsive enhancer-binding protein mediates hyperglycemia-induced inflammation and vascular and renal injury
SY Choi, SW Lim, S Salimi, EJ Yoo… - Journal of the …, 2018 - journals.lww.com
Diabetic nephropathy (DN) has become the single leading cause of ESRD in developed
nations. Bearing in mind the paucity of effective treatment for DN and progressive CKD,
novel targets for treatment are sorely needed. We previously reported that increased activity
of tonicity-responsive enhancer-binding protein (TonEBP) in monocytes was associated with
early DN in humans. We now extend these findings by testing the hypotheses that TonEBP
in macrophages promotes hyperglycemia-mediated proinflammatory activation and chronic …
nations. Bearing in mind the paucity of effective treatment for DN and progressive CKD,
novel targets for treatment are sorely needed. We previously reported that increased activity
of tonicity-responsive enhancer-binding protein (TonEBP) in monocytes was associated with
early DN in humans. We now extend these findings by testing the hypotheses that TonEBP
in macrophages promotes hyperglycemia-mediated proinflammatory activation and chronic …
