[HTML][HTML] Effect of a 28-d treatment with L-796568, a novel β3-adrenergic receptor agonist, on energy expenditure and body composition in obese men
TM Larsen, S Toubro, MA van Baak… - The American journal of …, 2002 - Elsevier
Background: Stimulation of energy expenditure (EE) with selective thermogenic β-
adrenergic agonists may be a promising approach for treating obesity. Objective: We
analyzed the effects of the highly selective human β 3-adrenergic agonist L-796568 on 24-h
EE, substrate oxidation, and body composition in obese, weight-stable men. Design: In this 2-
center, double-blind, randomized, parallel-group study, we measured 24-h EE before and
after 28 d of treatment with L-796568 (375 mg/d) or placebo during weight maintenance (ie …
adrenergic agonists may be a promising approach for treating obesity. Objective: We
analyzed the effects of the highly selective human β 3-adrenergic agonist L-796568 on 24-h
EE, substrate oxidation, and body composition in obese, weight-stable men. Design: In this 2-
center, double-blind, randomized, parallel-group study, we measured 24-h EE before and
after 28 d of treatment with L-796568 (375 mg/d) or placebo during weight maintenance (ie …