[HTML][HTML] The role of circadian clocks in metabolic disease
MD Li, CM Li, Z Wang - The Yale journal of biology and medicine, 2012 - ncbi.nlm.nih.gov
MD Li, CM Li, Z Wang
The Yale journal of biology and medicine, 2012•ncbi.nlm.nih.govThe circadian clock is a highly conserved timing system, resonating physiological processes
to 24-hour environmental cycles. Circadian misalignment is emerging as a risk factor of
metabolic disease. The molecular clock resides in all metabolic tissues, the dysfunction of
which is associated with perturbed energy metabolism. In this article, we will review current
knowledge about molecular mechanisms of the circadian clock and the role of clocks in the
physiology and pathophysiology of metabolic tissues.
to 24-hour environmental cycles. Circadian misalignment is emerging as a risk factor of
metabolic disease. The molecular clock resides in all metabolic tissues, the dysfunction of
which is associated with perturbed energy metabolism. In this article, we will review current
knowledge about molecular mechanisms of the circadian clock and the role of clocks in the
physiology and pathophysiology of metabolic tissues.
Abstract
The circadian clock is a highly conserved timing system, resonating physiological processes to 24-hour environmental cycles. Circadian misalignment is emerging as a risk factor of metabolic disease. The molecular clock resides in all metabolic tissues, the dysfunction of which is associated with perturbed energy metabolism. In this article, we will review current knowledge about molecular mechanisms of the circadian clock and the role of clocks in the physiology and pathophysiology of metabolic tissues.
ncbi.nlm.nih.gov
