The link between cell-cycle dependent radiosensitivity and repair pathways: A model based on the local, sister-chromatid conformation dependent switch between …
A Hufnagl, L Herr, T Friedrich, M Durante… - DNA repair, 2015 - Elsevier
The different DNA damage repair pathways like homologous recombination (HR) and non-
homologous end joining (NHEJ) have been linked to the variation of radiosensitivity
throughout the cell cycle. However, no attempts have been made to test the various
hypotheses derived from these studies in a quantitative way eg by using modeling
approaches. Here we present the first modeling approach that allows predicting the cell
cycle dependent radiosensitivity of repair proficient as well as of repair deficient cell lines …
homologous end joining (NHEJ) have been linked to the variation of radiosensitivity
throughout the cell cycle. However, no attempts have been made to test the various
hypotheses derived from these studies in a quantitative way eg by using modeling
approaches. Here we present the first modeling approach that allows predicting the cell
cycle dependent radiosensitivity of repair proficient as well as of repair deficient cell lines …