Transcriptomic features of cribriform and intraductal carcinoma of the prostate

Z Lone, T Benidir, M Rainey, M Nair, E Davicioni… - European Urology …, 2022 - Elsevier
Background Cribriform (CF) and/or intraductal carcinoma (IDC) are associated with more
aggressive prostate cancer (CaP) and worse outcomes. Objective The transcriptomic
features that typify CF/IDC are not well described and the capacity for clinically utilized
genomic classifiers to improve risk modeling for CF/IDC remains undefined. Design, setting,
and participants We performed a retrospective review of CaP patients who had Decipher
testing at a single high-volume institution. Index lesions from radical prostatectomy …