Traumatic brain injury and risk of neurodegenerative disorder

BL Brett, RC Gardner, J Godbout, K Dams-O'Connor… - Biological …, 2022 - Elsevier
Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for
specific dementia subtypes being more variable. Among the limited studies involving
neuropathological (postmortem) confirmation, the association between TBI and risk for
neurodegenerative disease increases in complexity, with polypathology often reported on
examination. The heterogeneous clinical and neuropathological outcomes associated with …