[HTML][HTML] Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion
A Zakaria, C Berthault, B Cosson, V Jung… - Journal of Biological …, 2021 - ASBMB
Glucose-mediated signaling regulates the expression of a limited number of genes in
human pancreatic β-cells at the transcriptional level. However, it is unclear whether glucose
plays a role in posttranscriptional RNA processing or translational control of gene
expression. Here, we asked whether glucose affects posttranscriptional steps and regulates
protein synthesis in human β-cell lines. We first showed the involvement of the mTOR
pathway in glucose-related signaling. We also used the surface sensing of translation …
human pancreatic β-cells at the transcriptional level. However, it is unclear whether glucose
plays a role in posttranscriptional RNA processing or translational control of gene
expression. Here, we asked whether glucose affects posttranscriptional steps and regulates
protein synthesis in human β-cell lines. We first showed the involvement of the mTOR
pathway in glucose-related signaling. We also used the surface sensing of translation …