Normal placental development is essential for a healthy pregnancy, and is contingent upon
tight spatiotemporal regulation of gene expression. One level of transcriptional control is via
enhancer elements in the genome. Enhancers are distal cis-regulatory elements that can
impact gene expression regardless of their position or orientation. The study of enhancers in
the placenta is usually focused on one or two at a time, and the simultaneous identification
of all enhancers has been limited. However, such a holistic approach is necessary if we are …