Pathology of graft-versus-host disease in the gastrointestinal tract
K Washington, M Jagasia - Human pathology, 2009 - Elsevier
Graft-versus-host disease (GVHD), a common complication of hematopoietic stem cell
transplantation, is a clinical syndrome that requires synthesis of clinical, laboratory, and
histopathologic findings for diagnosis. The gastrointestinal (GI) tract is commonly affected,
and pathologists must recognize subtle morphologic alterations in GI mucosal biopsies to
make the diagnosis and to rule out other causes of GI dysfunction such as cytomegalovirus
infection and drug effects. This review summarizes the histopathologic features of GVHD in …
transplantation, is a clinical syndrome that requires synthesis of clinical, laboratory, and
histopathologic findings for diagnosis. The gastrointestinal (GI) tract is commonly affected,
and pathologists must recognize subtle morphologic alterations in GI mucosal biopsies to
make the diagnosis and to rule out other causes of GI dysfunction such as cytomegalovirus
infection and drug effects. This review summarizes the histopathologic features of GVHD in …