[HTML][HTML] Targeting CD73 to augment cancer immunotherapy
M Roh, DA Wainwright, JD Wu, Y Wan… - Current opinion in …, 2020 - Elsevier
Highlights•CD73 is a multifunctional ectoenzyme affecting both tumor cells and immune
cells.•CD73 has been hijacked by TME to promote tumor growth and metastasis.•Targeting
CD73 and other adenosinergic molecules orchestrates anti-tumor immunity.•CD73 blockade
achieves synergy in combination with conventional therapy and/or ICB.CD73 (ecto-5′-
nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and
metastasis. Its main function is to convert extracellular ATP to immunosuppressive …
cells.•CD73 has been hijacked by TME to promote tumor growth and metastasis.•Targeting
CD73 and other adenosinergic molecules orchestrates anti-tumor immunity.•CD73 blockade
achieves synergy in combination with conventional therapy and/or ICB.CD73 (ecto-5′-
nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and
metastasis. Its main function is to convert extracellular ATP to immunosuppressive …