[HTML][HTML] Rethinking the adenosine-A2AR checkpoint: implications for enhancing anti-tumor immunotherapy
RS Helms, JD Powell - Current Opinion in Pharmacology, 2020 - Elsevier
Adenosine signaling through A 2A R serves as a negative regulator of the immune system.
Unique to this suppressive pathway is its ability to impact numerous stromal and immune
cells. Additionally, tumors exhibit elevated concentrations of adenosine further advancing
the pathway's potential as a powerful target for activating anti-tumor immunity. The promise
of this therapeutic strategy has been repeatedly demonstrated in mice, but has so far only
yielded limited success in the clinic. Nonetheless, it is notable that many of these observed …
Unique to this suppressive pathway is its ability to impact numerous stromal and immune
cells. Additionally, tumors exhibit elevated concentrations of adenosine further advancing
the pathway's potential as a powerful target for activating anti-tumor immunity. The promise
of this therapeutic strategy has been repeatedly demonstrated in mice, but has so far only
yielded limited success in the clinic. Nonetheless, it is notable that many of these observed …