Anti–IFN-γ autoantibodies are strongly associated with HLA-DR* 15: 02/16: 02 and HLA-DQ* 05: 01/05: 02 across Southeast Asia
LETTERS TO THE EDITOR 945 with a few from Hong Kong, Japan, and Western countries
but originally from Southeast Asia. 6 This narrow ethnic and geographic distribution of
nAIGA-associated immunodeficiency suggests a critical interplay between unique genetic
and environmental factor (s). HLAs are among the strongest and reproducible genetic
factors associated with autoimmune diseases. 7 In a previous work, we documented a
strong association between HLA class II alleles, HLA-DRB1* 16: 02 and HLADQB1* 05: 02 …
but originally from Southeast Asia. 6 This narrow ethnic and geographic distribution of
nAIGA-associated immunodeficiency suggests a critical interplay between unique genetic
and environmental factor (s). HLAs are among the strongest and reproducible genetic
factors associated with autoimmune diseases. 7 In a previous work, we documented a
strong association between HLA class II alleles, HLA-DRB1* 16: 02 and HLADQB1* 05: 02 …