Inflammatory bowel disease (IBD) is characterized by dysregulation in both cytokines and responses to intestinal microbes, and proper regulation of pattern recognition receptor (PRR) signaling is critical for intestinal immune homeostasis. Altered functions for the IBD risk locus containing rs7554511, which encompasses the
Jie Yan, Matija Hedl, Clara Abraham
Human myeloid cells from rs7554511 C risk allele carriers demonstrate less cytokine secretion upon PRR stimulation compared with AA carriers.
Human MDMs (